Penrith will be going for an incredible fifth straight premiership victory in 2025.
However, Ivan Cleary will face an uphill struggle this year following the departures of Jarome Luai and James Fisher-Harris.
Penrith Panthers NRL full schedule and results 2025
| Round | Date | Match | Time | Venue |
| 1 | Sun. March 2 | Panthers 28 def. Sharks 22 | 3:30pm (AEDT) | Allegiant Stadium |
| 2 | Fri. March 14 | Panthers 32 def. by Roosters 38 | 8:05pm (AEDT) | CommBank Stadium |
| 3 | Thurs. March 20 | Storm 30 def. Panthers 24 | 8:00pm (AEDT) | AAMI Park |
| 4 | Thurs. March 27 | Rabbitohs 28 def. Panthers 18 | 8:00pm (AEDT) | Accor Stadium |
| 5 | Fri. April 4 | Panthers 18 def. by Cowboys 22 | 6:00pm (AEDT) | CommBank Stadium |
| 6 | Thurs. April 10 | Dolphins 30 def. Panthers 12 | 7:50pm (AEST) | Suncorp Stadium |
| 7 | Sat. April 19 | Roosters 12 def. by Panthers 40 | 7:35pm (AEST) | Allianz Stadium |
| 8 | Sat. April 26 | Panthers vs. Sea Eagles | 7:35pm (AEST) | CommBank Stadium |
| 9 | Sun. May 4 | Panthers vs. Broncos | 4:05pm (AEST) | Suncorp Stadium |
| 10 | Sat. May 10 | Cowboys vs. Panthers | 7:35pm (AEST) | Queensland Country Bank Stadium |
| 11 | – | BYE | – | – |
| 12 | Sat. May 24 | Panthers vs. Knights | 5:30pm (AEST) | Carrington Park |
| 13 | Sun. June 1 | Panthers vs. Eels | 4:05pm (AEST) | CommBank Stadium |
| 14 | Sun. June 8 | Tigers vs. Panthers | 4:05pm (AEST) | CommBank Stadium |
| 15 | – | BYE | – | – |
| 16 | Sat. June 21 | Warriors vs. Panthers | 3:00pm (AEST) | Go Media Stadium |
| 17 | Thurs. June 26 | Panthers vs. Bulldogs | 7:50pm (AEST) | CommBank Stadium |
| 18 | – | BYE | – | – |
| 19 | Sun. July 13 | Eels vs. Panthers | 4:05pm (AEST) | CommBank Stadium |
| 20 | Fri. July 18 | Panthers vs. Rabbitohs | 8:00pm (AEST) | CommBank Stadium |
| 21 | Sat. July 26 | Panthers vs. Tigers | 5:30pm (AEST) | CommBank Stadium |
| 22 | Sat. August 2 | Titans vs. Panthers | 3:00pm (AEST) | Cbus Super Stadium |
| 23 | Fri. August 8 | Knights vs. Panthers | 6:00pm (AEST) | McDonald Jones Stadium |
| 24 | Thurs. August 14 | Panthers vs. Storm | 7:50pm (AEST) | CommBank Stadium |
| 25 | Fri. August 22 | Panthers vs. Raiders | 6:00pm (AEST) | Glen Willow Oval |
| 26 | Thurs. August 28 | Bulldogs vs. Panthers | 7:50pm (AEST) | Accor Stadium |
| 27 | Sat. September 6 | Dragons vs. Panthers | 3:00pm (AEST) | WIN Stadium |
When do the Panthers have bye rounds in 2025?
Penrith’s bye rounds will be in Round 11, as well as in Round 15 and Round 28.