The North QLD Cowboys and Penrith Panthers are scheduled to meet in the National Rugby League (NRL) at Queensland Country Bank Stadium on Saturday, starting at 5:35AM ET.
Based on updated simulations, Dimers’ proven NRL model (see Dimers Pro for full access) predicts the Panthers as the most likely winner of the game.
“Our team has used the latest data to run 10,000 simulations of Saturday’s Panthers-Cowboys game,” said Pat Sharyon from Dimers.
“By incorporating recent updates and various other inputs, we estimate that the Panthers are more likely to win, while the Cowboys have a lower chance of victory.”
For a closer look at Saturday’s matchup, including best bets and picks, visit our interactive Panthers vs. Cowboys predictions page.
Cowboys vs. Panthers Prediction: Who Will Win Round 10 Game?
Using powerful machine learning and data, we have simulated the result of Saturday’s NRL matchup between the Panthers and Cowboys 10,000 times as part of our NRL predictions coverage.
Our leading predictive model gives the Panthers a 61% chance of defeating the Cowboys.
According to our model, the bookmakers have got it right, and the Panthers and Cowboys each have a 50% chance of covering the spread, while the over/under total of 48.5 has a 55% chance of staying under.
PanthersPanthers vs. Cowboys Odds
We have researched the best NRL odds in America for this game, which are listed here:
| Bet Type | Panthers | Cowboys |
|---|---|---|
| H2H (Moneyline) | -175 | +138 |
| Line (Spread) | -4.5 (-110) | +4.5 (-115) |
| Total | o48.5 (-108) | u48.5 (-115) |
All odds are correct at the time of publication and are subject to change.
Make the most of your sports betting experience by exploring our comprehensive list of US betting apps, and the latest sportsbooks in 2025, ensuring you never miss a top new-user deal.
Cowboys vs. Panthers Game-Day Updates and Essential Details
Saturday’s Australian rugby league action between the Cowboys and Panthers at Queensland Country Bank Stadium is scheduled to begin at 5:35AM ET.
- Who: Penrith Panthers vs. North QLD Cowboys
- Date: Saturday, May 10, 2025
- Time: 5:35AM ET/2:35AM PT
- Venue: Queensland Country Bank Stadium
The NRL is available to bet on in the US through all major sportsbooks, with there even being games played in Vegas each season as of 2024.
Dimers.com’s full preview of Saturday’s Panthers vs. Cowboys matchup includes our prediction, picks and the latest betting odds.
Before making any Panthers vs. Cowboys picks, be sure to check out the latest NRL predictions and betting advice from Dimers Pro.
Conclusion
We predict the Panthers, with a 61% win probability, will likely beat the Cowboys on Saturday.
AI and automation have enhanced this article to quickly deliver accurate Panthers vs. Cowboys insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.